/ THERAPEUTIC APPROACH
New therapeutic approach
for resistant hypertension
The baroloop project is a therapy approach currently under development, aimed at treating resistant hypertension. It works through selective and individualized vagus nerve stimulation – particularly when medication is no longer sufficient.
/ THE CONDITION
Resistant hypertension –
when medications are no
longer sufficient
Hypertension (arterial hypertension) is a growing global health burden. One in three adults is affected – and four out of five patients are not adequately treated.1
Chronically elevated blood pressure can lead to severe consequences such as myocardial infarction, renal failure, or stroke. When untreated, it is one of the leading causes of premature death.1
What does “resistant hypertension” mean?
In some patients, blood pressure cannot be sufficiently lowered despite pharmacotherapy. According to the guidelines of the European Society of Cardiology, this is called true resistant hypertension. This is a condition in which blood pressure remains uncontrolled despite taking three or more medications from different classes, including a diuretic.2
At least 5% of all patients with hypertension are affected — around 50 million people worldwide.3
1 World Health Organization (2023): Global report on hypertension: The race against a silent killer. ISBN978-92-4-008106-2
2 European Society of Cardiology (2024): Guidelines for the management of elevated blood pressure and hypertension. https://doi.org/10.1093/eurheartj/ehae178
3 Buso, G., et al. (2024): The global burden of resistant hypertension and potential treatment options. https://doi.org/10.15420/ecr.2023.51
/ mechanism of Action
Hypertension is the leading risk factor
for cardiovascular disease
New therapeutic approach: Targeted neurostimulation aims to permanently lower blood pressure.
33% of adults worldwide are affected by hypertension.1
Only 1 in 5 patients achieves target values with medication.1
Therapy resistance affects millions—with a high risk of myocardial infarction or stroke.1
1 World Health Organization (2023): Global report on hypertension: The race against a silent killer. ISBN 978-92-4-008106-2
/ Highlights of the baroloop therapy
How our therapeutic approach is intended
to contribute to lowering blood pressure
The vagus nerve is the tenth cranial nerve and a central element of the autonomic nervous system. It modulates sympathetic activity via the brainstem and thereby regulates unconscious bodily functions such as heart rate, respiration, digestion, and immune responses.
It is also involved in processes that enable a rapid and targeted reduction in blood pressure (baroreflex). baroloop uses exactly this mechanism with the aim of strengthening the body’s own signals for blood pressure regulation.1
1Qing, K., et al.(2018): B fibers are the best predictors of cardiac activity during vagus nerve stimulation. https://doi.org/10.1186/s42234-018-0005-8
ADDITIONAL INFORMATION FOR HEALTHCARE PROFESSIONALS